Drug promiscuity can also be evaluated from the reverse perspective, focusing instead on the ability of a single therapeutic agent to interact with multiple protein targets. The most comprehensive ...
Ion channels are transmembrane proteins specifically involved with the transport of inorganic ions like Na+, K+, Ca2+, or Cl-. Ion channels are “gated”, i.e. they open in response to a specific ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 24 (June 16, 2020), pp. 13437-13446 (10 pages) Pentameric ligand-gated ion channels (pLGICs) are ...
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