The New England Journal of Medicine

MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia

Waldenström's macroglobulinemia is an incurable, IgM-secreting lymphoplasmacytic lymphoma (LPL). The underlying mutation in this disorder has not been delineated. We performed whole-genome sequencing ...
Nature

Detection of MYD88 L265P in peripheral blood of patients with Waldenström’s Macroglobulinemia and IgM monoclonal gammopathy of undetermined significance

MYD88 is an adaptor molecule that has an important role in modulating Toll-like receptor and interleukin-1 receptor signaling through interactions with interleukin-1 receptor-associated kinase 4 ...
ascopubs.org

Detection of the MYD88 L265P mutation in Waldenström’s macroglobulinemia using a highly sensitive allele-specific PCR assay.

Long-term results of the phase II trial of the oral mTOR inhibitor everolimus (RAD001) in relapsed or refractory Waldenstrom macroglobulinemia. This is an ASCO Meeting Abstract from the 2012 ASCO ...
The American Journal of Managed Care

Report Recommends Strategy to Identify CLL in Patient With Posterior Uveitis

It is rare for patients with chronic lymphocytic leukemia (CLL) to present with ocular involvement, but a mutational test could help clinicians identify patients more quickly. Testing for myeloid ...
ascopubs.org

MYD88 L265P mutation and CDKN2A loss as early mutational events in primary central nervous system lymphomas.

C-Methionine PET (Met-PET) for a diagnosis algorithm for pseudoprogression (PsP), radiations necrosis (RN) and progression (P) after an indeterminate magnetic resonance imaging (MRI) in glioblastoma ...
Nature

Activation of TAK1 by MYD88 L265P drives malignant B-cell Growth in non-Hodgkin lymphoma

To validate predicted chromosomal events in single patients, primer sets were designed specifically for each abnormality using Primer-Blast (http://www.ncbi.nlm.nih ...
Medical Xpress

Mutation ID'd in Waldenstrom's macroglobulinemia

(HealthDay)—MYD88 L265P is a common, recurring mutation in patients with Waldenström's macroglobulinemia, according to a study published in the Aug. 30 issue of the New England Journal of Medicine.
Monthly Prescribing Reference

Mutation ID’d in Waldenström’s Macroglobulinemia

Human Y Chromosome Linked to Coronary Artery Disease Risk MYD88 L265P is a common, recurring mutation in patients with Waldenström's macroglobulinemia. (HealthDay News) – MYD88 L265P is a common, ...